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pentobarbital will lessen the level or result of piroxicam by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unknown.pentobarbital will reduce the extent or impact of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not encouraged; strong cytochrome P450 enzyme inducers decrea